journal articles
SELF-REPORTED FATIGUE AND ITS CROSS-SECTIONAL ASSOCIATIONS WITH PHYSICAL FUNCTION THROUGHOUT ADULTHOOD: THE INSPIRE-T COHORT
D. Matsumoto, J. Raffin, W.-H. Lu, S. Guyonnet, F. Pillard, Y. Rolland, B. Vellas, P. de Souto Barreto, for the IHU HealthAge INSPIRE/Open Science group
BACKGROUND: Fatigue negatively impacts health outcomes but its association with physical function across the adulthood remains unclear.
OBJECTIVES: This study described self-reported fatigue levels across age and sex categories, investigated the associations between fatigue and physical functions, and examined wheth-er age and sex moderated their associations.
DESIGN: Cross-sectional design.
SETTING: Community.
PARTICIPANTS: Nine hundred sixteen participants aged 20-100 years in the observational INSPIRE-T cohort study.
MEASUREMENTS: Participants were classified into four age categories. Fatigue was asses-sed using the Patient-Reported Outcomes Measurement Information System (Short Form v1.0 – Fatigue 8a) and physical function was assessed by handgrip strength (HGS, Kg), usual gait speed (UGS, m/s), both 5-repetition (5CR, s) and 30-sec chair rise tests (30sCR, times), isokinetic knee extension strength (IKES, N m), and maximum oxygen consumption (V̇O2 max, ml/kg/min). Multiple linear regressions were performed to examine the associations between fatigue and the physical function outcomes (all square-root-transformed). Interac-tions of fatigue with age and sex were considered.
RESULTS: Fatigue levels were the highest in people 75+ years. Women had a higher fatigue level than men. Fatigue was significantly associated with decreasing performance in UGS, HGS, 5CR, and 30sCR but not in IKES and V̇O2 max. Interaction analyses revealed that fa-tigue was associated with reduced UGS as people age (Fatigue × age: B = -0.002, 95% con-fidence interval = -0.003, -0.001). Sex did not moderate the association between fatigue and physical function.
CONCLUSIONS: Our study indicated that fatigue was negatively associated with several components of physical function. Although sex did not moderate the relationship between fatigue and physical function, the association between fatigue and low UGS was more pro-nounced with increasing age.
CITATION:
D. Matsumoto ; J. Raffin ; W.-H. Lu ; S. Guyonnet ; F. Pillard ; Y. Rolland ; B. Vellas ; P. de Souto Barreto ; for the IHU HealthAge INSPIRE/Open Science group (2024): Self-Reported Fatigue and Its Cross-Sectional Associations with Physi-cal Function throughout Adulthood: The INSPIRE-T Cohort. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2024.56