journal articles
THE ASSOCIATION OF APOE Ε4 STATUS WITH LOWER LIMB FUNCTION AND HANDGRIP STRENGTH IN OLDER ADULTS
M. Maltais, P. de Souto Barreto, Y. Rolland, B. Vellas, for the MAPT/DSA Study Group
J Frailty Aging 2019;8(2):62-66
Background/Objectives: Apolipoprotein (ApoE ε4) status has been associated with various cardiovascular diseases and Alzheimer’s Disease. Some studies have found a possible relationship between the presence of an ApoE ε4 allele and the decrease of motor function in healthy older adults. The objective of this study was to measure the cross-sectional and prospective associations of ApoE ε4 status with lower limb function and handgrip strength in older adults. Design: Longitudinal observational study using data from a randomized controlled trial.Setting: Community-dwelling older adults. Participants: 1300 older adults (≥70 years old) with ApoE ε4 status from the Multidomain Alzheimer’s Preventive Trial (MAPT) were followed for three years. Measurements: Lower-limb function was measured with the Short Physical Performance Battery (SPPB) and muscle strength was measured with a handgrip strength dynamometer. ApoE ε4 status was assessed with a blood draw. Mixed-effect linear regressions were used to examine cross-sectional as well as prospective associations between ApoE ε4 status and the outcomes. Results: No significant cross-sectional or prospective associations were found between ApoE ε4 status, lower-limb function and handgrip strength in our study. Conclusions: ApoE ε4 status was not associated with motor function in older adults.
CITATION:
M. Maltais ; P. de Souto Barreto ; Y. Rolland ; B. Vellas ; for the MAPT/DSA Study Group (2019): The association of ApoE ε4 status with lower limb function and handgrip strength in older adults. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2019.7